Work to make temporary repairs to the intersection is underway, and is expected to take several hours to complete.
The closure will begin after the morning rush and will allow contractors to place beams for the new southbound Loop 289 bridge.
Crews will place a hotmix overlay on the street, and the work will require various lane closures on Fourth Street from Indiana Avenue to Slide Road.
More than three miles of the road will be resurfaced at a cost of more than $1.2 million.
Construction work will begin next week to complete a phase of the Marsha Sharp Freeway project.
The repairs are on the concrete median barrier. The westbound Loop 289 shoulder and inside main lane are closed to traffic, as is the eastbound Loop 289 shoulder.
Message signs alerting motorists of the change were placed last week for northbound and southbound Slide Road traffic.
Repairs will be made to bridge joints on several structures along I-27.
Work on the $7.4 million project began in September 2012.
The closure is to allow hazmat response teams to complete hazardous material cleanup on the roadway.